A review of in silico toxicology approaches to support the safety assessment of cosmetics-related materials

In silico tools and resources are now used commonly in toxicology to support the “Next Generation Risk Assessment” (NGRA) of cosmetics ingredients or materials. This review provides an overview approaches that applied assess exposure hazard a cosmetic ingredient. For both exposure, databases existing information routinely. addition, for include use rules thumb systemic bioavailability as well physiologically-based kinetics (PBK) multi-scale models estimating internal at organ tissue level. (Internal) Thresholds Toxicological Concern applicable safety assessment low concentrations. The structural rules, (Quantitative) Structure-Activity Relationships ((Q)SARs) read-across most typically modelling predict hazard. Data from increasingly being brought together NGRA provide overall All reviewed terms their maturity robustness use.